A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission
Jan Stephan Wichers-Misterek, Annika M. Binder, Paolo Mesén-Ramírez, Lilian P. Dorner, Soraya Safavi, Gwendolin Fuchs, Tobias L. Lenz, Anna Bachmann, Danny W. Wilson, Friedrich Frischknecht, Tim‐Wolf Gilberger
Abstract
A key structural feature driving the transition between different life cycle stages of the malaria parasite is the unique three-membrane pellicle, consisting of the parasite plasma membrane (PPM) and a double membrane structure underlying the PPM termed the inner membrane complex (IMC). Additionally, there are numerous linearly arranged intramembranous particles (IMPs) linked to the IMC, which likely link the IMC to the subpellicular microtubule cytoskeleton.
Topics & Concepts
MalariaParasite hostingMicrotubuleVirologyBiologyTransmission (telecommunications)Computational biologyComputer scienceCell biologyImmunologyWorld Wide WebTelecommunicationsMosquito-borne diseases and controlMalaria Research and ControlInvertebrate Immune Response Mechanisms