Discovery of potent thieno[2,3-d]pyrimidine VEGFR-2 inhibitors: Design, synthesis and enzyme inhibitory evaluation supported by molecular dynamics simulations
Eman Z. Elrazaz, Rabah A.T. Serya, Nasser S. M. Ismail, Amgad Albohy, Dalal A. Abou El Ella, Khaled A. M. Abouzid
Topics & Concepts
ChemistryPyrimidineProtein Data Bank (RCSB PDB)Molecular dynamicsDocking (animal)Molecular modelStereochemistryEnzymeIC50Inhibitory postsynaptic potentialPyrimidine analogueCombinatorial chemistryBiochemistryIn vitroComputational chemistryBiologyNursingMedicineNeuroscienceSynthesis and biological activityBioactive Compounds and Antitumor AgentsSynthesis and Reactions of Organic Compounds