Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures
Zhonghui Tang, Yinqi Bai, Qi Fang, Yuchen Yuan, Qianwen Zeng, Shuling Chen, Tianyi Xu, Jianyu Chen, Li Tan, Chunqing Wang, Qian Li, Jinpei Lin, Zhuoxuan Yang, Xia Wu, Guowei Shi, Ji Wang, Changjun Yin, Jianping Guo, Shiping Liu, Sui Peng, Ming Kuang
Topics & Concepts
TranscriptomeImmunotherapyFunction (biology)Cancer researchBiologyTumor microenvironmentNicheKynurenineCell biologyComputational biologyImmunologyTryptophanImmune systemGeneTumor cellsGeneticsBiochemistryGene expressionAmino acidSingle-cell and spatial transcriptomicsCancer Immunotherapy and BiomarkersImmune Cell Function and Interaction