Poly-phosphocholination of liposomes leads to highly-extended retention time in mice joints
Weifeng Lin, Ronit Goldberg, Jacob Klein
Abstract
PMPCylated liposomes injected into mice joints show a massive increase in retention half-life compared with PEGylated liposomes (or hyaluronan, HA), making them promising candidates as boundary lubricants at articular cartilage, or as drug carriers.
Topics & Concepts
LiposomeMaterials scienceBiophysicsComposite materialChemical engineeringNanotechnologyEngineeringBiologyNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsPolymer Surface Interaction Studies