Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal
Gellan Alaa Mohamed Kamel, Eman Harahsheh, Shaimaa Hussein
Topics & Concepts
AcetaminophenMyeloperoxidasePharmacologyTLR4Tumor necrosis factor alphaOxidative stressApoptosisLiver injuryInflammationMedicinePeroxisome proliferator-activated receptorInterleukinProinflammatory cytokineHMGB1AntioxidantReceptorChemistryEndocrinologyInternal medicineCytokineBiochemistryDrug-Induced Hepatotoxicity and ProtectionLiver Disease and TransplantationLiver physiology and pathology