Prospects for the search for new biologically active compounds among the derivatives of the heterocyclic system of 1,2,4-triazole.
Sameliuk Yurii, А. Г. Каплаушенко, Natalia NEDOREZANIUK, Liusine OSTRETSOVA, Feodosiia DİAKOVA, B. V. Gutyj
Abstract
The authors are not native speakers of Turkish The purpose of this literature review was to systematize data from studies of the biological activity of 1,2,4-triazole derivatives with substituents in positions 4 and 5. The authors set the task of forming an idea of current directions in the selection of substitutions for 1,2,4-triazole based on research. As a result of the study, 75 literature sources were analyzed. This made it possible to form a further vector in terms of searching for biologically active structures among 1,2,4-triazole derivatives. The review develops a modern approach to the search for biologically active substances among 1,2,4-triazole derivatives. Systematized data on the nature of substituents in the core of 1,2,4-triazole, which affect a specific type of activity. The search material was selected over the past decade with the highest number of citations at the time of literature analysis.