Early precursors and molecular determinants of tissue-resident memory CD8 <sup>+</sup> T lymphocytes revealed by single-cell RNA sequencing
Nadia S. Kurd, Zhaoren He, Tiani L. Louis, J. Justin Milner, Kyla Omilusik, Wenhao Jin, Matthew Tsai, Christella E. Widjaja, Jad Kanbar, Jocelyn G. Olvera, Tiffani Tysl, Lauren K. Quezada, Brigid S. Boland, Wendy Huang, Cornelis Murre, Ananda W. Goldrath, G Yeo, John T. Chang
Abstract
Heterogeneity of small intestine intraepithelial CD8 + T cells suggests functionally distinct subsets of T RM cells and their precursors.
Topics & Concepts
Intraepithelial lymphocyteRNACD8BiologyCytotoxic T cellMolecular biologyCellImmunologyGeneticsAntigenGeneImmune systemIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics