Chitosan hydrogel for topical delivery of ebastine loaded solid lipid nanoparticles for alleviation of allergic contact dermatitis
Tasbiha Kazim, Abeer Tariq, Muhammad Usman, Muhammad Faisal Ayoob, Ahmad Khan
Abstract
studies were conducted on BALB/c mice to evaluate the topical efficacy of the E-SLNs loaded hydrogel for allergic contact dermatitis. ACD was induced on the ear using picryl chloride solution. After induction, ears were treated daily with the E-SLNs loaded hydrogel for 15 days. Swelling behavior, mast cell count, and histopathological studies of the ear confirmed that the hydrogel alleviated the symptoms of allergic contact dermatitis.
Topics & Concepts
Solid lipid nanoparticleZeta potentialChitosanContact dermatitisParticle sizeIn vivoAllergic contact dermatitisChemistryPharmacologyMaterials scienceNanoparticleChromatographyNanotechnologyMedicineAllergyOrganic chemistryImmunologyBiotechnologyPhysical chemistryBiologyAdvancements in Transdermal Drug DeliveryContact Dermatitis and AllergiesDermatology and Skin Diseases