The microglial P2Y6 receptor mediates neuronal loss and memory deficits in neurodegeneration
Mar Puigdellívol, Stefan Milde, Anna Vilalta, Tom O. J. Cockram, David H. Allendorf, Young Seok Lee, Jacob M. Dundee, Katryna Pampuščenko, Vilmantė Borutaitė, Hugh Nuthall, Jack Brelstaff, Maria Grazia Spillantini, Guy C. Brown
Abstract
receptor appears to mediate Aβ- and tau-induced neuronal and memory loss via microglial phagocytosis of neurons, suggesting that blocking this receptor may be beneficial in the treatment of neurodegenerative diseases.
Topics & Concepts
NeurodegenerationMicrogliaNeuroscienceReceptorBiologyMedicineInflammationInternal medicineDiseaseImmunologyGeneticsNeuroinflammation and Neurodegeneration MechanismsAdenosine and Purinergic SignalingTryptophan and brain disorders