Inducing a pH-dependent conformational response by competitive binding to Zn<sup>2+</sup> of a series of chiral ligands of disparate basicity
Matthew M. Wootten, Bryden A. F. Le Bailly, Sofja Tshepelevitsh, Ivo Leito, Jonathan Clayden
Abstract
A chemical system comprising a series of chiral acids of differing p K a , a metal, and a conformationally labile chromophore responds to pH with a CD spectrum that reports the absolute stereochemistry of the most basic anion in the mixture.
Topics & Concepts
ChemistryDeprotonationProtonationLigand (biochemistry)Circular dichroismStereochemistryEnantiomerChirality (physics)Conformational changeChemical shiftMoleculeCationic polymerizationCrystallographyIonReceptorOrganic chemistryPhysicsNambu–Jona-Lasinio modelPhysical chemistryBiochemistryQuantum mechanicsChiral symmetry breakingQuarkMolecular Sensors and Ion DetectionDNA and Nucleic Acid ChemistryLuminescence and Fluorescent Materials