Porous Cu-MOF nanostructures with anticancer properties prepared by a controllable ultrasound-assisted reverse micelle synthesis of Cu-MOF
Reza Akhavan‐Sigari, Malihe Zeraati, Mohammadreza Moghaddam‐Manesh, Parya Kazemzadeh, Sara Hosseinzadegan, Narendra Pal Singh Chauhan, Ghasem Sargazi
Abstract
Abstract The ultrasonic assisted reverse micelle method (UARM) was used to synthesize Cu-MOF from Cu(NO 3 ) 2 ·3H 2 O and 2,6-pyridine dicarboxylic acid in a 1:1 molar proportion. It has been characterized using FT-IR, XRD, nitrogen adsorption analysis, SEM and TEM–EDX. The morphology of Cu-MOFs was spherical, with an average particle size distribution of less than 100 nm. Using BET analysis, the surface area of Cu-MOF was found to be 284.94 m 2 /g. The porous morphology of Cu-MOF was also suggested by SEM and TEM analyses. It has anticancer properties against MCF-7 breast cancer cells. Cytotoxicity testing was performed on MCF-7 breast cancer cells using the MTT cell viability assay, and cell proliferation and viability were found to be approximately 24% higher than the control.