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Perfluorooctane sulfonate and perfluorooctanoic acid inhibit progesterone-responsive capacitation through cAMP/PKA signaling pathway and induce DNA damage in human sperm

Lijun Shan, Yuhao Chai, Tian Gao, Kun Li, Jianmin Yu, Fei Liang, Ya Ni, Peibei Sun

2023Environmental Toxicology and Pharmacology22 citationsDOI

Topics & Concepts

CapacitationPerfluorooctaneSpermPerfluorooctanoic acidAcrosome reactionChemistryHuman fertilizationDNA damageHyperactivationDNA fragmentationAndrologyEndocrinologyInternal medicineBiologyBiochemistryCell biologySulfonateDNAApoptosisProgrammed cell deathMedicineGeneticsOrganic chemistrySodiumPer- and polyfluoroalkyl substances researchBirth, Development, and Health
Perfluorooctane sulfonate and perfluorooctanoic acid inhibit progesterone-responsive capacitation through cAMP/PKA signaling pathway and induce DNA damage in human sperm | Litcius