Heterosynthons, Solid Form Design and Enhanced Drug Bioavailability
Ashwini Nangia, Gautam R. Desiraju
Abstract
Starting from a molecular pharmacophore, which is a marker of drug action in medicinal molecules, we propose that the heterosynthon, a supramolecular synthon between unlike functional groups, plays an analogous role in the design and discovery of high bioavailability drugs. The heterosynthon could provide a more efficient and economical route to novel drugs.
Topics & Concepts
PharmacophoreSynthonBioavailabilityDrugChemistryCombinatorial chemistryDrug discoveryPharmacologySupramolecular chemistryStereochemistryMoleculeMedicineBiochemistryOrganic chemistryCrystallography and molecular interactionsChemical Synthesis and AnalysisComputational Drug Discovery Methods