XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
Eva Domenjo‐Vila, Valentina Casella, Ryutaro Iwabuchi, Even Fossum, Mireia Pedragosa, Quim Castellví, Paula Cebollada Rica, Tsuneyasu Kaisho, Kazutaka Terahara, Gennady Bocharov, Jordi Argilaguet, Andreas Meyerhans
Abstract
subsets, while increase of SIRPα+ DCs dampened their proliferation. Together, this demonstrates that XCR1+ DCs are crucial for the success of checkpoint inhibitor-based therapies through differential activation of exhausted CD8+ T cell subsets.
Topics & Concepts
CD8ImmunologyImmunotherapyCytotoxic T cellDendritic cellT cellImmune systemCancer researchMedicineBiologyIn vitroBiochemistryImmunotherapy and Immune ResponsesImmune Cell Function and InteractionT-cell and B-cell Immunology