Protective effect of phillyrin against cerebral ischemia/reperfusion injury in rats and oxidative stress-induced cell apoptosis and autophagy in neurons
Shu Chen, Shan Zhang, Honggang Wu, Daobao Zhang, Guoliang You, Jing You, Niandong Zheng
Abstract
-induced neuronal apoptosis and autophagy. Taken together, phillyrin alleviates I/R injury by inhibiting neuronal cell apoptosis and autophagy pathway, which may provide a new treatment strategy for cerebral I/R injury.
Topics & Concepts
PI3K/AKT/mTOR pathwayAutophagyApoptosisProtein kinase BLactate dehydrogenaseViability assayReperfusion injuryIschemiaNeuroprotectionBiologyChemistryPharmacologyMedicineInternal medicineBiochemistryEnzymeAutophagy in Disease and TherapySirtuins and Resveratrol in MedicineBiological and pharmacological studies of plants