Organoid-based single-cell spatiotemporal gene expression landscape of human embryonic development and hematopoiesis
Yiming Chao, Yang Xiang, Jiashun Xiao, Weizhong Zheng, Mo R. Ebrahimkhani, Can Yang, Angela Ruohao Wu, Pentao Liu, Yuanhua Huang, Ryohichi Sugimura
Abstract
The cell-cell interactions are fundamental mechanisms of differentiating embryonic tissues. 1 We aimed to model human embryonic development in stem-cell-derived organoids. We exploited the time series single-cell and spatial transcriptomics to reveal the gene expression landscape in the development of embryonic tissues and their interactions.
Topics & Concepts
Embryonic stem cellOrganoidBiologyHaematopoiesisGeneGene expressionCell biologyComputational biologyStem cellCellCancer researchGeneticsSingle-cell and spatial transcriptomicsPluripotent Stem Cells ResearchCancer Genomics and Diagnostics