Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing <i>CCNB1</i> expression
Min Li, Hua Shang, Tao Wang, Shui-Qing Yang, Lei Li
Abstract
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent cancers in human populations worldwide. Huanglian decoction is one of the most important Chinese medicine formulas, with the potential to treat cancer. AIM: To investigate the role and mechanism of Huanglian decoction on HCC cells. METHODS: gene was knocked down to verify the primary target of this decoction. Through the identification of the expression levels of key proteins, we determined the primary mechanism of Huanglian decoction in HCC. RESULTS: was significantly decreased. The p53 signaling pathway was also found to play an important role in this process. CONCLUSION: to activate the p53 signaling pathway.
Topics & Concepts
Hepatocellular carcinomaDecoctionMedicineInternal medicineCancer researchOncologyGastroenterologyImmunologyUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysFerroptosis and cancer prognosis