Novel Biomarker-Based Score (Sad-60) for Predicting Mortality in Patients with Covid-19 Pneumonia: A Multicenter Retrospective Cohort of 1013 Patients
Serkan Sürme, Gülşah Tunçer, Osman Faruk Bayramlar, Betül Çopur, Esra Zerdalı, İnci Yılmaz Nakir, Meltem Yazla, Ahmet Buyukyazgan, Ayse RK Cinar, Yeşim Kürekçi, Mustafa Alkan, Yusuf Emre Özdemir, Gönül Şengöz, Filiz Pehlıvanoglu
Abstract
Background: The aim was to explore a novel risk score to predict mortality in hospitalized patients with COVID-19 pneumonia. Methods: This was a retrospective, multicenter study. Results: A total of 1013 patients with COVID-19 were included. The mean age was 60.5 ± 14.4 years, and 581 (57.4%) patients were male. In-hospital death occurred in 124 (12.2%) patients. Multivariate analysis revealed peripheral capillary oxygen saturation (SpO2), albumin, D-dimer and age as independent predictors. The mortality score model was given the acronym SAD-60, representing SpO2, Albumin, D-dimer, age ≥60 years. The SAD-60 score (0.776) had the highest area under the curve compared with CURB-65 (0.753), NEWS2 (0.686) and qSOFA (0.628) scores. Conclusion: The SAD-60 score has a promising predictive capacity for mortality in hospitalized patients with COVID-19.