Development of a pH-sensitive functionalized metal organic framework:<i>in vitro</i>study for simultaneous delivery of doxorubicin and cyclophosphamide in breast cancer
Ragini Singh, Binayak Kumar, Ram Krishna Sahu, Soni Kumari, Chandan Bhogendra Jha, Nahar Singh, Rashi Mathur, Suresh Hedau
Abstract
sustained release characteristics (76% of DOX and 80% of CP) by cleavage of chemical bonding and disruption of the MOFs structure under acidic condition (at pH 5.6). Moreover, DOX@ZIF-8/GO-FA/CP has synergistic cytotoxic effects as compared to the combination of both the drugs without ZIF-8/GO-FA when treating MCF-7 and MDA-MB-231 breast cancer cell lines (with a combination index of 0.29 and 0.75 for MCF-7 and MDA-MB-231 cell-lines, respectively). Hence this system can be applied as an effective platform for smart dual drug delivery in breast cancer treatment through its remarkable manageable multidrug release.
Topics & Concepts
DoxorubicinCyclophosphamideIn vitroBreast cancerChemistryCombinatorial chemistryCancer researchPharmacologyCancerMedicineInternal medicineChemotherapyBiochemistryMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers