Main drivers of (poly)phenol effects on human health: metabolite production and/or gut microbiota-associated metabotypes?
Carlos E. Iglesias‐Aguirre, Adrián Cortés‐Martín, María Ángeles Ávila‐Gálvez, Juan Antonio Giménez‐Bastida, María V. Selma, Antonio González‐Sarrías, Juan Carlos Espı́n
Abstract
, gut microbiota-associated metabotypes). However, statistical associations between health effects and the occurrence of circulating and/or excreted metabolites, as well as cross-sectional studies that correlate gut microbial ecologies and health, do not prove a causal role unequivocally. We provide a critical overview and perspective on the possible main drivers of the effects of (poly)phenols on human health and suggest possible actions to identify the putative actors responsible for the effects.
Topics & Concepts
MetabolitePhenolHuman healthGut floraFood scienceChemistryBiologyBiochemistryEnvironmental healthMedicineOrganic chemistryNutritional Studies and DietDiet and metabolism studiesFatty Acid Research and Health