Genome-based discovery and total synthesis of janustatins, potent cytotoxins from a plant-associated bacterium
Reiko Ueoka, Philipp Sondermann, Stefan Leopold‐Messer, Yizhou Liu, Rei Suo, Agneya Bhushan, Lida Vadakumchery, Ute Greczmiel, Yoko Yashiroda, Hiromi Kimura, Shinichi Nishimura, Yojiro Hoshikawa, Minoru Yoshida, Annette Oxenius, Shigeki Matsunaga, R. Thomas Williamson, Erick M. Carreira, Jörn Piel
Topics & Concepts
ChemistryBacteriaGenomeTotal synthesisComputational biologyDrug discoveryStereochemistryBiochemistryGeneticsGeneBiologyMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsPhytochemical compounds biological activities