RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
Martin Andrš, Zdenka Hašanová, Anna Oravetzova, Jana Dobrovolná, Pavel Janščák
Abstract
to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
Topics & Concepts
Genome instabilityHelicaseHomologous recombinationBiologyGeneticsTranscription (linguistics)RAD51DNA replicationDNA repairCell biologyDNARNA polymerase IINucleoproteinDNA damageGeneRNAPromoterGene expressionLinguisticsPhilosophyDNA Repair MechanismsPARP inhibition in cancer therapyCarcinogens and Genotoxicity Assessment