Silver-catalyzed cyclopropanation of alkenes with alkynyl <i>N</i>-nosylhydrazones leading to alkynyl cyclopropanes
Yongquan Ning, Mengtian Huo, Lizuo Wu, Xihe Bi
Abstract
-nosylhydrazones as alkynyl carbene precursors, is reported. This method provides a straightforward and powerful approach for preparing various alkynyl cyclopropanes in high yield with excellent stereoselectivities. In addition, the practicality of this method was demonstrated by gram-scale synthesis and late-stage modification of bioactive molecules.
Topics & Concepts
CyclopropanationCarbeneYield (engineering)ChemistryCatalysisStereoselectivityCombinatorial chemistryOrganic chemistryMaterials scienceMetallurgyCyclopropane Reaction MechanismsCatalytic Alkyne ReactionsCatalytic C–H Functionalization Methods