The Role of IgE Sensitization in Acute FPIES: A Systematic Review and Meta-Analysis
A. Phelan, Sonsoles Infante, Simona Barni, Ulugbek Nurmatov, Robert Boyle, Marta Vázquez‐Ortiz
Abstract
BACKGROUND: Evidence on the role of immunoglobulin E (IgE) sensitization in acute food protein-induced enterocolitis syndrome (atypical FPIES) is limited. Initial reports claimed association with persistent disease; however, recent studies have not replicated this. OBJECTIVE: To systematically review the relationship between sensitization to the culprit food(s) in acute FPIES and the outcome of follow-up oral food challenges. To assess the rates of sensitization, seroconversion (ie, switch from negative tests to sensitization), and phenotype switch to IgE-mediated food allergy over time in individuals with acute FPIES. METHODS: Systematic review searching 10 databases. Studies of children and adults with an acute FPIES diagnosis assessing IgE sensitization to a culprit food at onset or follow-up measured by skin prick or serological test were included. RESULTS: = 18%) of sensitized participants. CONCLUSIONS: We did not find consistent evidence for the relationship between IgE sensitization and FPIES persistence. We found phenotype switch to IgE-mediated food allergy is uncommon in acute FPIES. An IgE sensitization in FPIES does not have a clear relationship with clinical outcomes.