The long intergenic noncoding RNA GAS5 reduces cisplatin-resistance in non-small cell lung cancer through the miR-217/LHPP axis
Xuhui Yang, Lifei Meng, Yuang Zhong, Fengqing Hu, Lei Wang, Mingsong Wang
Abstract
, GAS5 upregulation inhibited remarkably NSCLC/DDP cell tumor growth. Mechanism analysis suggested that GAS5 was a molecular sponge of miR-217, inhibiting the expression of phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP). In conclusion, this study reveals that the GAS5/miR-217/LHPP pathway reduces NSCLC cisplatin resistance and that LHPP may serve as a potential therapeutic target for NSCLC cisplatin resistance.
Topics & Concepts
Intergenic regionGAS5Long non-coding RNAmicroRNANon-coding RNALung cancerCancer researchCisplatinBiologyRNAGeneticsMedicineGeneOncologyGenomeChemotherapyCancer-related molecular mechanisms researchRNA modifications and cancerCircular RNAs in diseases