Litcius/Paper detail

Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors

Abdel‐Ghany A. El‐Helby, Helmy Sakr, Rezk R. Ayyad, Hazem A. Mahdy, Mohamed M. Khalifa, Amany Belal, Mahmoud Rashed, Abdou El-Sharkawy, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Ibrahim H. Eissa

2020Bioorganic Chemistry68 citationsDOI

Topics & Concepts

PhthalazineChemistryTopoisomeraseIn vivoDNAIn vitroIntercalation (chemistry)DNA damageIC50Docking (animal)StereochemistryBiochemistryCell cycleApoptosisBiologyMedicinal chemistryNursingBiotechnologyInorganic chemistryMedicineCancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and biological activity