Design, synthesis, molecular modeling, in vivo studies and anticancer activity evaluation of new phthalazine derivatives as potential DNA intercalators and topoisomerase II inhibitors
Abdel‐Ghany A. El‐Helby, Helmy Sakr, Rezk R. Ayyad, Hazem A. Mahdy, Mohamed M. Khalifa, Amany Belal, Mahmoud Rashed, Abdou El-Sharkawy, Ahmed M. Metwaly, Mostafa A. Elhendawy, Mohamed M. Radwan, Mahmoud A. ElSohly, Ibrahim H. Eissa
Topics & Concepts
PhthalazineChemistryTopoisomeraseIn vivoDNAIn vitroIntercalation (chemistry)DNA damageIC50Docking (animal)StereochemistryBiochemistryCell cycleApoptosisBiologyMedicinal chemistryNursingBiotechnologyInorganic chemistryMedicineCancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and biological activity