Cinnamaldehyde–cucurbituril complex: investigation of loading efficiency and its role in enhancing cinnamaldehyde <i>in vitro</i> anti-tumor activity
Bayan Al Tbakhi, Hamdi Nsairat, Walhan Alshaer, Abdulfattah Al-Kadash, Wissam Helal, Lubna Alrawashdeh, Anthony I. Day, Khaleel I. Assaf, Rola Hassouneh, Fadwa Odeh, Abeer Al Bawab
Abstract
values for free Cinn and CB[7]-Cinn inclusion complexes were 240.17 ± 32.46 μM and 260.47 ± 20.83 μM against U-87 cells and 85.93 ± 3.35 μM and 176.3 ± 7.79 μM against MDA-MB-231 cells, respectively, despite the enhanced aqueous solubility. No significant cytotoxicity was noticed for the free CB[7].
Topics & Concepts
CinnamaldehydeCucurbiturilIn vitroChemistryBiochemistryOrganic chemistrySupramolecular chemistryMoleculeCatalysisSupramolecular Chemistry and ComplexesBoron Compounds in ChemistryNanoparticle-Based Drug Delivery