Hydrogen Atom Transfer‐Mediated Domino Cyclisation Reaction to Access (Spiro)Quinazolinones
Oliver Turner, David J. Hirst, John A. Murphy
Abstract
Abstract A radical domino cyclisation reaction of N ‐cyanamide alkenes, mediated by hydrogen atom transfer (HAT) has been developed. This method, using PhSiH 3 and catalytic Fe(acac) 3 , allows for the synthesis of challenging (spiro)quinazolinone scaffolds from simple, tractable (hetero)aryl carboxylic acid and cyanamide building blocks.
Topics & Concepts
DominoHydrogen atomChemistryDomino effectTransfer (computing)Combinatorial chemistryAtom (system on chip)Cascade reactionComputer scienceCatalysisOrganic chemistryPhysicsParallel computingGroup (periodic table)Nuclear physicsQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and ActivitiesAdvanced Synthetic Organic Chemistry