LncRNAs associated with glioblastoma: From transcriptional noise to novel regulators with a promising role in therapeutics
Bhupender Yadav, Sonali Pal, Yury Rubstov, Akul Goel, Manoj Garg, Marat S. Pavlyukov, Amit Kumar Pandey
Abstract
Glioblastoma multiforme (GBM) is the most widespread and aggressive subtype of glioma in adult patients. Numerous long non-coding RNAs (lncRNAs) are deregulated or differentially expressed in GBM. These lncRNAs possess unique regulatory functions in GBM cells, ranging from high invasion/migration to recurrence. This review outlines the present status of specific involvement of lncRNAs in GBM pathogenesis, with a focus on their association with key molecular and cellular regulatory mechanisms. Also, we highlighted the potential of different novel RNA-based strategies that may be beneficial for therapeutic purposes.
Topics & Concepts
GlioblastomaLong non-coding RNAGliomaBiologyPathogenesisCancer researchComputational biologyNeuroscienceBioinformaticsRNAGeneGeneticsImmunologyCancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancer