GABA receptor inhibition and severe hypoxia induce a paroxysmal depolarization shift in goldfish neurons
Nariman Hossein‐Javaheri, Leslie T. Buck
Abstract
This work shows that the combination of anoxia and inhibition of GABA receptors induces seizure-like activities in goldfish telencephalic pyramidal and stellate neurons. Importantly, to prevent seizure-like activity, an intact GABA-mediated inhibitory pathway is required.
Topics & Concepts
DepolarizationExcitatory postsynaptic potentialGABAA receptorNeuroscienceInhibitory postsynaptic potentialHyperpolarization (physics)NeurotransmissionGABAergicGABAB receptorPostsynaptic potentialBiologyChemistryGlutamatergicReceptorGlutamate receptorBiophysicsBiochemistryNuclear magnetic resonance spectroscopyOrganic chemistryNeuroscience and Neuropharmacology ResearchSleep and Wakefulness ResearchZebrafish Biomedical Research Applications