Computational and Experimental Approaches to Investigate Lipid Nanoparticles as Drug and Gene Delivery Systems
Chun Chan, Shi Du, Yizhou Dong, Xiaolin Cheng
Abstract
was the first LNPs-based drug approved by the US Food and Drug Administration (FDA). Since then, with decades of research and development, more and more LNP-based therapeutics have been used to treat diverse diseases, which often offer the benefits of reduced toxicity and/or enhanced efficacy compared to the active ingredients alone. Here, we provide a review of recent advances in the development of efficient and robust LNPs for drug/gene delivery. We emphasize the importance of rationally combining experimental and computational approaches, especially those providing multiscale structural and functional information of LNPs, to the design of novel and powerful LNP-based delivery systems.
Topics & Concepts
Drug deliveryDrugGene deliveryComputational biologyFood and drug administrationNanotechnologyMedicinePharmacologyBiologyGeneGenetic enhancementMaterials scienceGeneticsLipid Membrane Structure and BehaviorRNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery