Synchronous targeted delivery of TGF-β siRNA to stromal and tumor cells elicits robust antitumor immunity against triple-negative breast cancer by comprehensively remodeling the tumor microenvironment
Mengmeng Yang, Chao Qin, Linlin Tao, Gang Cheng, Jingjing Li, Fangnan Lv, Nan Yang, Zuhang Xing, Xinyu Chu, Xiaopeng Han, Meirong Huo, Lifang Yin
Topics & Concepts
Tumor microenvironmentCancer researchStromal cellTriple-negative breast cancerCancer cellCD44ImmunotherapyCytotoxic T cellImmune systemCancer immunotherapyBiologyCell biologyImmunologyCellCancerBreast cancerIn vitroGeneticsBiochemistryCancer Cells and MetastasisCell Adhesion Molecules ResearchNanoplatforms for cancer theranostics