Mechanical response of cardiac microtissues to acute localized injury
Shoshana L. Das, Bryan P. Sutherland, Emma Lejeune, Jeroen Eyckmans, Christopher S. Chen
Abstract
We report an in vitro cardiac injury model that uses a high-powered laser to induce regional cell death and a focal fibrotic response within a human-engineered cardiac microtissue. The model captures the effects of acute injury on tissue response, remodeling, and electromechanical recovery in both the damaged region and surrounding healthy tissue, modeling similar changes to contractile function observed in vivo following myocardial infarction.
Topics & Concepts
In vivoMedicineMyocardial infarctionCardiac function curveHeart failureMyofibroblastFibrosisVimentinCardiologyInternal medicinePathologyBiologyBiotechnologyImmunohistochemistryTissue Engineering and Regenerative MedicineCardiac Fibrosis and RemodelingCardiac Ischemia and Reperfusion