<i>N</i>-methyl-<scp>d</scp>-aspartate receptor hyperfunction contributes to <scp>d</scp>-serine-mediated renal insufficiency
Yi-Shiou Tseng, Chun‐Hou Liao, Wen‐Bin Wu, Ming‐Chieh Ma
Abstract
-methyl-d-aspartate receptors (NMDARs) are not only present in the nervous system but also expressed in the kidney. Overstimulation of renal NMDARs leads to oxidative stress via the signal pathway of calcium/protein kinase C/NADPH oxidase in d-serine-mediated tubular cell damage. Intervention of NMDAR blockade may prevent acute renal injury caused by d-serine.
Topics & Concepts
NADPH oxidaseChemistryNMDA receptorSuperoxideEndocrinologyInternal medicineSerineProtein kinase COxidative stressReceptorPharmacologyBiochemistryKinaseBiologyMedicinePhosphorylationEnzymeAmino Acid Enzymes and MetabolismSulfur Compounds in BiologyNitric Oxide and Endothelin Effects