Altered dorsal CA1 neuronal population coding in the APP/PS1 mouse model of Alzheimer’s disease
Udaysankar Chockanathan, Emily J. Warner, Loel C. Turpin, M. Kerry O’Banion, Krishnan Padmanabhan
Abstract
While the link between amyloid β (Aβ) accumulation and synaptic degradation in Alzheimer's disease (AD) is known, the consequences of this pathology on population coding remain unknown. We found that the entropy, a measure of the diversity of network firing patterns, was lower in the dorsal CA1 region in the APP/PS1 mouse model of Aβ pathology, relative to controls, thereby reducing the population's coding capacity. Our results reveal a network level signature of the deficits Aβ accumulation causes to the computations performed by neural circuits.
Topics & Concepts
DiseaseDorsumCoding (social sciences)PopulationAlzheimer's diseaseNeuroscienceBiologyBioinformaticsMedicinePathologyAnatomyMathematicsEnvironmental healthStatisticsAlzheimer's disease research and treatmentsNeuroscience and Neuropharmacology ResearchMemory and Neural Mechanisms