Design and synthesis of proteolysis targeting chimeras (PROTACs) as an EGFR degrader based on CO-1686
Qinlan Li, Qian Guo, Shuyi Wang, Shanhe Wan, Zhonghuang Li, Jiajie Zhang, Xiaoyun Wu
Topics & Concepts
T790MProteolysisChemistryEpidermal growth factor receptorProteasomeCell cultureProtein degradationCell growthCancer researchPharmacologyReceptorBiochemistryEnzymeMedicineBiologyGefitinibGeneticsProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways