Tailored assemblies of COPII proteins in secretion
Vivek Malhotra
Abstract
Export of secretory cargoes from the endoplasmic reticulum (ER) requires COPII proteins, which were first identified for their ability to coat small vesicles that bud from the ER. Recent data indicate that COPII proteins can also organize into a collar at the necks of tubules, as well as phase-separate into liquid-like condensates. Thus, COPII assemblies seem to be tailored to accommodate variations in the size and quantities of cargo secreted.
Topics & Concepts
COPIISecretionCell biologySecretory proteinChemistrySecretory pathwayBiologyBiochemistryGolgi apparatusEndoplasmic reticulumCellular transport and secretionRNA regulation and diseaseRNA Research and Splicing