A Simple and Convenient Method for Synthesis ofArtemisinin Dimer through Aliphatic Nitro Compounds
Nitin Srivastava, B.K. Rathore, R.K. Vishnoi, Sangeeta Bajpai
Abstract
A simple way of synthesis of artemisinin dimer using nitro aliphatic compounds is reported. Herein, few artemisinin monomers and dimers have been synthesized with the help of linker nitroalkanes using iron catalyst supported on polymer (Fe/SBA-15). The synthesized artemisinin shows good anticancer and antimalarial activities
Topics & Concepts
ArtemisininChemistryDimerNitroCombinatorial chemistryLinkerCatalysisMonomerNitro compoundOrganic chemistryPolymerMalariaPlasmodium falciparumComputer scienceAlkylOperating systemBiologyImmunologyChemical Synthesis and AnalysisSynthesis and Biological EvaluationSynthesis and Reactivity of Heterocycles