siRNA targeting Schlemm’s canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model
Paul Cassidy, Ruth A. Kelly, Ester Reina‐Torres, Joseph M. Sherwood, Marian M. Humphries, Anna‐Sophia Kiang, G. Jane Farrar, Colm O’Brien, Matthew Campbell, W. Daniel Stamer, Darryl R. Overby, Pete Humphries, Jeffrey O’Callaghan
Abstract
, with a concomitant increase in conventional outflow facility in a well-characterized chronic steroid-induced mouse model of ocular hypertension, thus representing a potential focused clinical application for this therapy in a sight-threatening scenario.
Topics & Concepts
Trabecular meshworkSchlemm's canalDexamethasoneGlaucomaIntraocular pressureTight junctionMyocilinDownregulation and upregulationEndothelial stem cellSmall interfering RNAParacellular transportMedicineChemistryCell biologyOphthalmologyBiologyEndocrinologyCell cultureIn vitroTransfectionBiochemistryGeneticsPermeability (electromagnetism)MembraneGeneGlaucoma and retinal disordersRetinal Diseases and TreatmentsCerebral Venous Sinus Thrombosis