Natural Products and Altered Metabolism in Cancer: Therapeutic Targets and Mechanisms of Action
Wamidh H. Talib, Media Mohammed Baban, Mais Fuad Bulbul, Esraa Al-Zaidaneen, Aya Allan, Eiman Wasef Al-Rousan, Rahaf Hamed Yousef Ahmad, Heba K. Alshaeri, Moudi M. Alasmari, Douglas Law
Abstract
Cancer is characterized by uncontrolled cell proliferation and the dysregulation of numerous biological functions, including metabolism. Because of the potential implications of targeted therapies, the metabolic alterations seen in cancer cells, such as the Warburg effect and disruptions in lipid and amino acid metabolism, have gained attention in cancer research. In this review, we delve into recent research examining the influence of natural products on altered cancer metabolism. Natural products were selected based on their ability to target cancer's altered metabolism. We identified the targets and explored the mechanisms of action of these natural products in influencing cellular energetics. Studies discussed in this review provide a solid ground for researchers to consider natural products in cancer treatment alone and in combination with conventional anticancer therapies.