Dietary phytosterol supplementation mitigates renal fibrosis <i>via</i> activating mitophagy and modulating the gut microbiota
Fan Yang, Yingjie Gao, Siyi Xie, Wenjing Yang, Qiyan Wang, Wenqian Ye, Lu Sun, Jiangtao Zhou, Xiue Feng
Abstract
the PINK1/Parkin pathway and modulate the gut microbiota, thereby alleviating renal fibrosis. The findings provide solid and significant implications for developing effective application of PS supplementation in the management of CKD, presenting novel concepts and approaches for research and clinical treatment.
Topics & Concepts
Gut floraMitophagyPhytosterolKidney diseaseFibrosisMedicineKidneyInternal medicineBiologyImmunologyAutophagyFood scienceBiochemistryApoptosisLiver Disease Diagnosis and TreatmentChronic Kidney Disease and DiabetesAutophagy in Disease and Therapy