The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
Sabelo Lukhele, Diala Abd Rabbo, Mengdi Guo, Jian Shen, Heidi Elsaesser, Rene Quevedo, Madeleine Carew, Ramy Gadalla, Laura M. Snell, Lawanya Mahesh, Marion Ciudad, Bryan E. Snow, Annick You-Ten, Jillian Haight, Andrew Wakeham, Pamela S. Ohashi, Tak W. Mak, Weiguo Cui, Tracy L. McGaha, David G. Brooks
Topics & Concepts
BiologyImmune systemCD8Transcription factorCancer researchT cellImmunologyEffectorInterferonImmunityGeneticsGeneImmune Cell Function and InteractionT-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers