The design and synthesis of potent benzimidazole derivatives <i>via</i> scaffold hybridization and evaluating their antiproliferative and proapoptotic activity against breast and lung cancer cell lines
Mohamed Saleh Elgawish, Mohamed S. Nafie, Asmaa S. A. Yassen, Koji Yamada, Nagat Ghareb
Abstract
New series of benzimidazole bearing scaffold as powerful antiproliferative antiangiogenic compounds against breast (MCF-7) and lung (A549) cell lines cancer were designed using molecular hybridization as a new strategy for drug development.
Topics & Concepts
ChemistryBenzimidazoleScaffoldCancer cell linesCell cultureCancer researchBreast cancerLung cancerCancerCancer cellOncologyInternal medicineBiomedical engineeringGeneticsOrganic chemistryMedicineBiologyClick Chemistry and ApplicationsSynthesis and biological activityChemical Synthesis and Analysis