A comprehensive review of challenges and advances in exosome-based drug delivery systems
Sushesh Srivatsa Palakurthi, Sushesh Srivatsa Palakurthi, Brijesh Shah, Sumedha Kapre, Nitin B. Charbe, Susan Immanuel, Sindhura Pasham, Maharshi Thalla, Ankit Jain, Srinath Palakurthi, Srinath Palakurthi
Abstract
, which may unlock the potential of exosomes in clinical applications. A few reports based on hybrid exosomes involving hybridization between different cell/tumor/macrophage-derived exosomes with synthetic liposomes through membrane fusion have shown to overcome some limitations associated with natural or synthetic exosomes. Yet, sufficient evidence is indispensable to prove their stability and clinical efficacy.
Topics & Concepts
ExosomeDrug deliveryKey (lock)MicrovesiclesDrugMedicineNanotechnologyComputer scienceData sciencePharmacologyChemistrymicroRNAMaterials scienceComputer securityBiochemistryGeneExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMicroRNA in disease regulation