Fast Carbon Isotope Exchange of Carboxylic Acids Enabled by Organic Photoredox Catalysis
Duanyang Kong, Maxime Munch, Qiqige Qiqige, Christopher Cooze, Benjamin H. Rotstein, Rylan J. Lundgren
Abstract
Carbazole/cyanobenzene photocatalysts promote the direct isotopic carboxylate exchange of C(sp3) acids with labeled CO2. Substrates that are not compatible with transition-metal-catalyzed degradation–reconstruction approaches or prone to thermally induced reversible decarboxylation undergo isotopic incorporation at room temperature in short reaction times. The radiolabeling of drug molecules and precursors with [11C]CO2 is demonstrated.
Topics & Concepts
ChemistryDecarboxylationCatalysisCarbon fibersCarboxylateTransition metalPhotochemistryCarbazoleMoleculeOrganic chemistryCombinatorial chemistryComposite numberMaterials scienceComposite materialChemical Reactions and IsotopesFluorine in Organic ChemistryCarbon dioxide utilization in catalysis