A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L. Meagher, Renqi Xu, Yu Wang, Wei Jiang, Hoda Metwally, Paul D. Kirchhoff, Lijie Zhao, Hui Jiang, Meilin Wang, Bo Wen, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang
Topics & Concepts
STAT5STAT proteinCancer researchstatSmall moleculeIn vivoChemistryCell growthBiologyCell biologySignal transductionSTAT3BiochemistryGeneticsProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways