FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation
Yunki Lim, Brandon Berry, Stephanie Viteri, Matthew N. McCall, Eun Chan Park, Christopher Rongo, Paul S. Brookes, Keith Nehrke
Abstract
AL: autolysosome; AP: autophagosome; FUNDC1: FUN14 domain containing 1; HR: hypoxia-reperfusion; IR: ischemia-reperfusion; lof: loss of function; MQC: mitochondrial quality control; PCA: principle component analysis; PPP: pentonse phosphate pathway; proK (proteinase K);UPRmt: mitochondrial unfolded protein response; RNAi: RNA interference.
Topics & Concepts
MitophagyBiologyAutophagyHypoxia (environmental)Cell biologyGeneticsOxygenApoptosisOrganic chemistryChemistryAutophagy in Disease and TherapyCancer, Hypoxia, and MetabolismAdenosine and Purinergic Signaling