Nucleoside-modified AdoMet analogues for differential methyltransferase targeting
Nicolas V. Cornelissen, Freideriki Michailidou, Fabian Muttach, Kristina Rau, Andrea Rentmeister
Abstract
-modification changed the relative activity of three representative MTases up to 13-fold resulting in discrimination of substrates for the methyl transfer and could also be combined with transfer of allyl and propargyl groups.
Topics & Concepts
MethyltransferaseNucleosideChemistryBiomoleculeEnzymeStereochemistryMethionineCofactorBiochemistryMethylationDNAAmino acidRNA modifications and cancerCancer-related gene regulationEpigenetics and DNA Methylation