Multi-omics analysis reveals the anti-fatigue mechanism of BCAA-enriched egg white peptides: the role of the gut–muscle axis
Shengrao Li, Jingbo Liu, Qi Yang, Siwen Lyu, Qing‐Wen Han, Menghan Fu, Zhiyang Du, Xuanting Liu, Ting Zhang
Abstract
. BEWPs also regulated the levels of key metabolites in mouse muscles, including L-glutamic acid by arginine biosynthesis and bile secretion pathways. Notably, Spearman's correlation analysis indicated that there was a significant correlation between these altered metabolites, microbial populations, and indicators of fatigue. In summary, our research demonstrated that BEWPs alleviated fatigue through the gut-muscle axis, which provided new insights into fatigue management and prevention.
Topics & Concepts
Mechanism (biology)Muscle fatigueAmino acidChemistryBiochemistryCell biologyComputational biologyBiologyNeurosciencePhilosophyEpistemologyElectromyographyMuscle metabolism and nutritionExercise and Physiological ResponsesBiochemical effects in animals