Metal ions doping effect on the physicochemical, antimicrobial, and wound healing profiles of alginate-based composite
Liudmyla Sukhodub, Liudmyla Sukhodub, Mariia Kumeda, Л. Ф. Суходуб, Л. Ф. Суходуб, Volodymyr Bielai, Mykola Lyndіn
Abstract
The alginate (Alg) matrix with immobilized hydroxyapatite (HAp) and zinc oxide (ZnO), cross-linked by chitosan (CS) and metal ions (Men+) Ca2+, Zn2+, and Cu2+ was created as a wound dressing. The effect of Men+ and their concentrations on water vapor transition, fluid handling, dehydration, drug release, and healing are shown. Me-containing samples have a lower sorption capacity, than a commercial Kaltostat, however, a much lower degree of their dehydration provides a longer wound wet. The Men+ presence lowers the environmental pH to slightly acidic values promoting healing. Ca2+, Zn2+, and Cu2+ in complexes with CS increase antimicrobial effect against E. coli and S. aureus, slow down the Anaesthesine release, making it compatible with Fickian diffusion in the Zn2+ and Cu2+ presence, and non-Fickian transport under Ca2+ influence. The material promotes the proliferation of the fibroblasts, an increase of collagen fibres, and new arterial and venous capillaries, indicating the intensity of the healing process.